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8 cpt  (Tocris)


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Bioz Manufacturer Symbol Tocris manufactures this product  
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    Structured Review

    Tocris 8 cpt
    8 Cpt, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 32 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/8+cpt+2me+camp/8-CPT-2Me-cAMP%2C+sodium+salt/pm40398411-264-22-26
    Average 94 stars, based on 32 article reviews
    8 cpt - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Activation Assay:

    Article Title: cAMP and voltage modulate rat auditory mechanotransduction by decreasing the stiffness of gating springs
    Article Snippet: .. For the activation of the Epac pathway, a 5 mM stock solution of 8-CPT-2Me-cAMP (Tocris, 1645) was prepared by dissolving the drug in water. ..

    Membrane:

    Article Title: Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3
    Article Snippet: For pharmacological investigation of the cAMP-GluA3 dependent pathway the following membrane permeable drugs were added to the bath of ACSF: 50 μM Forskolin (adenylyl cyclase activator, Sigma), 20 μM H89 (PKA antagonist, Tocris), 5 μM KT5720 (PKA antagonist, Sigma), and 10 μM ESI-05 (EPAC antagonist, BioLog). .. In addition, we applied the membrane non-permeable agonist for EPAC, 8-CPT-2Me-cAMP (20 μM, Tocris Bioscience) to the intracellular whole cell recording solution to investigate the postsynaptic impact of EPAC. .. In order to obtain a monophasic time decay of the AMPA-evoked responses in outside-out patches we added a final mixture of 80 μM PEPA (AMPAR flop splice variant desensitization blocker, Tocris bioscience) and 100 μM cyclothiazide (CTZ, AMPAR flip splice variant desensitization blocker, Tocris bioscience) to the bath solution.

    Synthesized:

    Article Title: Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine
    Article Snippet: .. The buffer was then replaced with fresh aCSF and slices were treated with tyramine (1, 10, 100 μM; Sigma-Aldrich, St. Louis, MO, United States), T 1 AM (1, 10, 100 μM; synthesized by Servier, kind gift from Mark J. Millan), β-PEA (100 μM; Sigma-Aldrich), SCH23390 (5 μM; Sigma-Aldrich), EPPTB (10 nM, synthesized by Servier, kind gift from Mark J. Millan), KN-92 (10 μM; Sigma-RBI), H-89 (10 μM; Calbiochem, Gibbstown, NJ, United States) and 8-CPT-2Me-cAMP (10 μM; Tocris Bioscience, Bristol, United Kingdom), alone or in combination. ..

    other:

    Article Title: Adenylate cyclase 10 promotes brown adipose tissue thermogenesis
    Article Snippet: 8-CPT-2Me-cAMP , Tocris , 1645.

    Article Title: Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3
    Article Snippet: For investigation of the cAMP-GluA3-dependent pathway, we used FSK (Sigma), H89 (Tocris), KT5720 (Sigma), ESI-05 (BioLog), and 8-CPT-2Me-cAMP (Tocris Bioscience).



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    Image Search Results


    Journal: iScience

    Article Title: Adenylate cyclase 10 promotes brown adipose tissue thermogenesis

    doi: 10.1016/j.isci.2025.111833

    Figure Lengend Snippet:

    Article Snippet: Brown adipocytes were treated with 5 μΜ AG-221, 1 mM acetazolamide (Sigma), 10 μΜ KH7 (MedChemExpress), 50 μΜ LRE1 (MedChemExpress), 10 μΜ H89 (Selleckchem), 10 μΜ (R)-CE3F4 (MedChemExpress), 100 μΜ 8-CPT-2Me-cAMP (Tocris), 10 μΜ CPI-613 (Cayman), 1 μΜ CL316,243 (MedChemExpress), 1 μΜ isoproterenol (Sigma) or respective controls as indicated in the figure legends.

    Techniques: Recombinant, Transfection, cAMP Assay, Activity Assay, Software

    Information on small molecular compounds.

    Journal: Pharmaceutics

    Article Title: Small Molecule Cocktails Promote Fibroblast-to-Leydig-like Cell Conversion for Hypogonadism Therapy

    doi: 10.3390/pharmaceutics15102456

    Figure Lengend Snippet: Information on small molecular compounds.

    Article Snippet: 8-CPT-2Me-cAMP , Rap1 activation , MCE (Cat. No: HY-1075 43) , 2 μM , 507.82 , .

    Techniques: Concentration Assay, Molecular Weight, Inhibition, Activation Assay